Peptide Database

Peptide NameLL-23

Function Ontology

Anticancer

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Standard StatusStandard

Sequence Length23 amino acids

Chemical FormulaC124H220N38O32

DescriptionStandard

        LLGDLLRKSKEKIGKEFKRIVQR
    

Molecular Weight2755.31 Da

Isoelectric Point (pI)10.55

Net Charge (pH 7.0)4.76

Net Charge (pH 7.4) 4.55

Charge Density (pH 7.0) 0.2070

GRAVY Index-0.76

Hydrophobic Moment 0.92

Boman Index-0.36

Instability Index14.50

Aliphatic Index 114.35

Aromaticity 0.0435

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1194.54

LogP -8.60

H-bond Donors 43.0

H-bond Acceptors 37.0

Rotatable Bonds 104.0

Heavy Atoms 194.0

Ring Count 1.0

Amide Bonds 23.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0343589 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral Cytotoxic Anticancer

TargetCEM-SS cells

Activity>35

MethodTC50

PaperAnti-human immunodeficiency virus type 1 activities of antimicrobial peptides derived from human and bovine cathelicidins. Antimicrob Agents Chemother. 2008 Sep;52(9):3438-3440. doi: 10.1128/AAC.00452-08. PMID: 18591279. PMID18591279 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18591279/

RECORD: Rec_0345617 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyCathelicidin

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Entry inhibition

TargetHIV-1IIIB | CEM-SS cells

Activity35.4 μM

MethodEC50

Half-LifeMammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min

PaperAnti-human immunodeficiency virus type 1 activities of antimicrobial peptides derived from human and bovine cathelicidins. | Wang G, Watson KM, Buckheit RW Jr. | Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. | DOI:10.1128/AAC.00452-08 | PMID:18591279 PMID18591279 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18591279/

RECORD: Rec_0407444 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyCathelicidin

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hemolytic

TargetCEM-SS cells 50% cell death at >35.4 microM

Activity35.4 μM

MethodHemolysis

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