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MYP_062666
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Basic Information
#5650 derived from HIV-1 integrase
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Reverse transcriptase inhibition
Standard
15 amino acids
C66H111N21O22S3
Standard
Sequence
KCQLKGEAMHGQVDC
Physicochemical Analysis
1646.91 Da
6.73
-0.17
-0.46
-0.0114
-0.61
0.10
-0.12
4.19
52.00
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
712.22
-8.12
25.0
26.0
58.0
112.0
1.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0101975 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Replication inhibition
HIV-1
30 μM
% inhibition
Mammalian: 1.3 h; Yeast: 3 min; E. coli: 2 min
PaperInhibition of human immunodeficiency virus type-1 reverse transcriptase by a novel peptide derived from the viral integrase. | Oz Gleenberg I, Herschhorn A, Goldgur Y, Hizi A. | Arch Biochem Biophys. 2007 Feb 15;458(2):202-12. | DOI:10.1016/j.abb.2006.12.007 | PMID:17257575 PMID17257575 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17257575/
RECORD: Rec_0197593 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Reverse transcriptase inhibition
Qualitative inhibition
PaperInhibition of human immunodeficiency virus type-1 reverse transcriptase by a novel peptide derived from the viral integrase. PMID17257575 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17257575/
RECORD: Rec_0230434 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1: inhibition of reverse transcriptase(RNA-dependent DNA polymerase) activity(63± 3% residual DNA polymerase activity at 30 μM)
PaperPubMed PMID: 17257575 PMID17257575 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17257575/
RECORD: Rec_0310804 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1[60-70% RT activity = 30 microM
PMID17257575 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17257575/
RECORD: Rec_0384027 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 17257575 PMID17257575 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17257575/
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