Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length418 amino acids

Chemical FormulaC2069H3298N518O592S13

DescriptionStandard

        EEDGSPLVSLVPPKVSSSALREVLLATFAPGLPAGGILNLGLPKSQVRLVPGTGVSLSIGDAFINLHGNWRVKYLRIIQDSGSFDLAVSGLSISTTINRPMVSGVNCQAVVGSAKIRFHGGTSWLYNLFSKFVDQALYEKHVLKVLISSKNVLLFQICPLVDEYAEIEYSMVESPVVSNSNIDLSLKGEFYNIGQHKEPPFSPNPFSLPPQDSNMLYIGLSAFTINSAGFVYNSAGALSLYITDDMIPSSPIRLSTRTFGAFIPQIAKQYPGLMMKLLVKTVKEPTITFEPDNVTLQVQSAVTAYAIQPKSTLSPLFVLNLNASVSAKIYVEGVKVAGTLTLNEIDMALAKSYVGPFDVRSLNNIILMVLKIMVIPKVNARLEEGFPLPAIGKMNLVNTQLQILKGYMLIGTDIQFTA
    

Molecular Weight45318.28 Da

Isoelectric Point (pI)8.37

Net Charge (pH 7.0)2.19

Net Charge (pH 7.4) 1.70

Charge Density (pH 7.0) 0.0052

GRAVY Index0.29

Hydrophobic Moment 0.62

Boman Index0.20

Instability Index42.53

Aliphatic Index 110.26

Aromaticity 0.0837

Extinction Coeff. Reduced 31860.00

Extinction Coeff. Oxidized 31985.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0096139 VERIFIED: NO

Provenance & Taxonomy

OrganismPygocentrus nattereri [Bacterium]

FamilyBPI

Tax ID42514

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence