Peptide Database

Peptide NameUnnamed

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor

Standard StatusStandard

Sequence Length45 amino acids

Chemical FormulaC243H423N69O68S

DescriptionStandard

        RMKQIEDKIEEIESKQKKIENEIARIKKLLQLTVWGIKQLQARIL
    

Molecular Weight5431.44 Da

Isoelectric Point (pI)9.78

Net Charge (pH 7.0)3.77

Net Charge (pH 7.4) 3.54

Charge Density (pH 7.0) 0.0838

GRAVY Index-0.63

Hydrophobic Moment 0.66

Boman Index-0.21

Instability Index92.22

Aliphatic Index 123.56

Aromaticity 0.0222

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2313.47

LogP -15.81

H-bond Donors 79.0

H-bond Acceptors 73.0

Rotatable Bonds 204.0

Heavy Atoms 381.0

Ring Count 2.0

Amide Bonds 50.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0192365 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Fusion inhibition

TargetHIV-1 | 293T cells; HOS-CD4/fusion cells

Activity0.19±0.03 μM

MethodIC50

Half-LifeMammalian: 1 h; Yeast: 2 min; E. coli: 2 min

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