Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length181 amino acids

Chemical FormulaC913H1424N252O242S9

DescriptionStandard

        PLAQQPMLLLAVTQHLANSAAFTYFMSGALRRNISSAMLPRRFPLQLRTRSMGLYFPQLQEHYPDYPMELQLWARQQPLLSCHPDALHGTLLGSAEAFVVLPNATRVPAFLLNIDANVTGKPSISRNRLGGTVKLTDPWGQAGAQPCPVPQVKRLENLLKFGLWLFGVPWANSECCPHPVP
    

Molecular Weight20091.20 Da

Isoelectric Point (pI)9.51

Net Charge (pH 7.0)6.37

Net Charge (pH 7.4) 5.97

Charge Density (pH 7.0) 0.0352

GRAVY Index-0.04

Hydrophobic Moment 0.61

Boman Index0.11

Instability Index65.53

Aliphatic Index 92.21

Aromaticity 0.0884

Extinction Coeff. Reduced 27960.00

Extinction Coeff. Oxidized 28210.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7754.42

LogP -82.66

H-bond Donors 264.0

H-bond Acceptors 262.0

Rotatable Bonds 628.0

Heavy Atoms 1416.0

Ring Count 45.0

Amide Bonds 200.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0250837 VERIFIED: NO

Provenance & Taxonomy

OrganismBucco capensis [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria