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MYP_062532
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Basic Information
T649v
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
not Standard
37 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XTWXEWDREINNYTSLIHSLIEESQNQQEKNEQELLE
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0212325 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
The 'X' at position 1 indicates Norleucine
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 20660316 PMID20660316 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20660316/
RECORD: Rec_0228577 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
cyclic peptide architecture [Cyclic]
noncanonical stereochemical modification [Modified]
None
None
The 'X' at position 1 indicates Norleucine.
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 HxB2 | Cf2Th-CD4-CXCR4 cells
0.0029±0.0004 μM
IC50
PaperHydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic. | Bird GH, Madani N, Perry AF, Princiotto AM, Supko JG, He X, Gavathiotis E, Sodroski JG, Walensky LD. | Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14093-8. | DOI:10.1073/pnas.1002713107 | PMID:20660316 PMID20660316 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20660316/
RECORD: Rec_0231150 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
The 'X' at position 1 indicates Norleucine
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1 YU2:inhibition of virus infection in Cf2Th-CD4-CCR5 cells
3 μM
IC50
PaperPubMed PMID: 20660316 PMID20660316 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20660316/
RECORD: Rec_0300825 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
cyclic peptide architecture [Cyclic]
noncanonical stereochemical modification [Modified]
None
None
The 'X' at position 1 indicates Norleucine.
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 V38E/N42S | Cf2Th-CD4-CXCR4 cells
0.0444±0.0065 μM
IC50
PaperHydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic. | Bird GH, Madani N, Perry AF, Princiotto AM, Supko JG, He X, Gavathiotis E, Sodroski JG, Walensky LD. | Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14093-8. | DOI:10.1073/pnas.1002713107 | PMID:20660316 PMID20660316 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20660316/
RECORD: Rec_0301785 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 1,4
Bio-Activity Profile
Antiviral
HIV-1 HxB2
PMID20660316 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20660316/
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