Peptide Database

Peptide NameAtrial natriuretic factor

Function Ontology

Cardiovascular

Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide

Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Hormonal / Endocrine ▸ Hormone peptide

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Reproductive biology ▸ Reproductive modulation

Standard StatusStandard

Sequence Length28 amino acids

Chemical FormulaC128H207N45O40S3

DescriptionStandard

        SLRRSSCFGGRMDRIGAQSSLGCNSFRY
    

Molecular Weight3112.49 Da

Isoelectric Point (pI)10.66

Net Charge (pH 7.0)3.44

Net Charge (pH 7.4) 3.20

Charge Density (pH 7.0) 0.1229

GRAVY Index-0.51

Hydrophobic Moment 0.60

Boman Index-0.23

Instability Index89.75

Aliphatic Index 45.36

Aromaticity 0.1071

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1423.61

LogP -20.90

H-bond Donors 56.0

H-bond Acceptors 47.0

Rotatable Bonds 105.0

Heavy Atoms 216.0

Ring Count 3.0

Amide Bonds 29.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0049793 VERIFIED: NO

Provenance & Taxonomy

OrganismCavia porcellus [Animal]

FamilyAtrial natriuretic factor

Tax ID10141

Structure & Mods

Configlinear peptide with reported disulfide constraint [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

Disulfide7-23

Other Mods6:Phosphoserine

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasodilator Cardiovascular Metabolic regulation Physiological regulation Reproductive regulator Receptor modulation ACE inhibitory

Half-LifeMammalian: 1.9 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0209632 VERIFIED: NO

Provenance & Taxonomy

OrganismCavia porcellus [Animal]

FamilyAtrial natriuretic factor

Tax ID10141

Structure & Mods

Configlinear peptide with reported disulfide constraint [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

Disulfide7-23

Other Mods6:Phosphoserine

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasodilator Cardiovascular Metabolic regulation Physiological regulation Reproductive regulator Receptor modulation ACE inhibitory

Targetadipose tissue

Half-LifeMammalian: 1.9 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0352920 VERIFIED: NO

Provenance & Taxonomy

OrganismCavia porcellus [Animal]

FamilyNatriuretic peptide

Tax ID10141

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide7-23

Bio-Activity Profile

Function

Hormone Cardiovascular