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MYP_062429
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Basic Information
Brevinin-1TSa
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
22 amino acids
C102H175N27O28
Standard
Sequence
FLGSIVGALASALPSLISKIRN
Physicochemical Analysis
2227.64 Da
11.00
1.76
1.55
0.0800
1.07
0.52
0.37
17.23
150.91
0.0455
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
877.56
-8.13
31.0
30.0
73.0
157.0
2.0
22.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0265853 VERIFIED: YES
Provenance & Taxonomy
Rana tsushimensis [Animal]
Brevinin
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Pseudomonas aeruginosa ATCC 27853
50 μM
MIC
PMID16413829 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16413829/
RECORD: Rec_0291731 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Toxic Hemolytic
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0300544 VERIFIED: YES
Provenance & Taxonomy
Rana tsushimensis [Animal]
Brevinin
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
PMID16413829 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16413829/
RECORD: Rec_0329608 VERIFIED: YES
Provenance & Taxonomy
Rana tsushimensis [Animal]
Brevinin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antifungal
PaperJ.M. Conlon et al. / Comparative Biochemistry and Physiology, Part C 143 (2006) 42-49. Antimicrobial peptides from the skin of the Tsushima brown frog Rana tsushimensis
RECORD: Rec_0331513 VERIFIED: YES
Provenance & Taxonomy
Rana tsushimensis [Animal]
Brevinin
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus aureus NCTC 8325
25 μM
MIC
PMID16413829 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16413829/
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