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MYP_062419
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Basic Information
Magainin-2 [G3K; K4,10,11,14Dap; F5W; A15K; G18Dap; E19Dap; M21Nle]
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
23 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
GIKXWLHSAXXFGXKFVXXIXNS
Physicochemical Analysis
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0142067 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Magainin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
X(4/10/11/14/18/19)=Dap; X(21)=Nle
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
HEK293
100 μM
EC50
PaperPubMed PMID: 31161686 PMID31161686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31161686/
RECORD: Rec_0221640 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Magainin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
X(4/10/11/14/18/19)=Dap; X(21)=Nle
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PaperPubMed PMID: 31161686 PMID31161686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31161686/
RECORD: Rec_0257931 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Magainin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
X(4/10/11/14/18/19)=Dap; X(21)=Nle
Bio-Activity Profile
Antimicrobial Anticancer
PANC-1
55±1.8 μM
EC50
PaperPubMed PMID: 31161686 PMID31161686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31161686/
RECORD: Rec_0387108 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Magainin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
X(4/10/11/14/18/19)=Dap; X(21)=Nle
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
Human kidney-derived GM cells
19
EC50
PaperPubMed PMID: 31161686 PMID31161686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31161686/