Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length264 amino acids

Chemical FormulaC1339H2102N342O386S5

DescriptionStandard

        MEKPILKNLNEMLCPIIASEVKALNANLSTLEVLTKIDNYTLLDYSLISSPEITENYLDLNLKGVFYPLENLADPPFSPVPFVLPERSNSMLYIGIAEYFFKSASFAYFTAGAFNVTLSTKEISNHFVQNSQGLGNVLSRVASTSVGLVILGQRLVCSLSLNRFRLALPESNRSNIEVLRFENILSSILHFGVLPLANAKLQRGFPLPNPHKISFVNSDIEVLEGFLLISTNLKYETSSKQQPSFHGWEGLNLISGQWRGKSAP
    

Molecular Weight29327.40 Da

Isoelectric Point (pI)6.44

Net Charge (pH 7.0)-1.14

Net Charge (pH 7.4) -1.65

Charge Density (pH 7.0) -0.0043

GRAVY Index0.09

Hydrophobic Moment 0.63

Boman Index0.14

Instability Index43.76

Aliphatic Index 107.08

Aromaticity 0.0985

Extinction Coeff. Reduced 22920.00

Extinction Coeff. Oxidized 23045.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0244759 VERIFIED: NO

Provenance & Taxonomy

OrganismRhinopithecus bieti [Animal]

FamilyBPI

Tax ID61621

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence