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MYP_062242
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Basic Information
ENF (T-20)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Anti-Pneumovirus ▸ Anti-RSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Standard
36 amino acids
C202H298N50O64
Standard
Sequence
YTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWF
Physicochemical Analysis
4450.82 Da
4.30
-5.14
-5.41
-0.1427
-0.88
0.46
-0.05
62.65
89.44
0.1389
17990.00
17990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1894.02
-14.96
63.0
60.0
150.0
316.0
9.0
42.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0243524 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
LAI
1163.33±102.94
IC50
PMID30716118 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30716118/
RECORD: Rec_0258193 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
JR-CSF
2968.33±788.34
IC50
PMID30716118 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30716118/
RECORD: Rec_0262498 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
Enfuvirtide
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
PM-1
95 %
Inhibition
PaperMembrane-anchored peptide inhibits human immunodeficiency virus entry. PMID11222732 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11222732/
RECORD: Rec_0264788 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
CH040.c/2625
30883.33±3805.27
IC50
PMID30716118 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30716118/
RECORD: Rec_0264968 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 92BR020 | U87 cells
0.3 μg/mL
IC50
Mammalian: 2.8 h; Yeast: 10 min; E. coli: 2 min
PaperOptimization of peptidic HIV-1 fusion inhibitor T20 by phage display. | Chen G, Cook JD, Ye W, Lee JE, Sidhu SS. | Protein Sci. 2019 Aug;28(8):1501-1512. | DOI:10.1002/pro.3669 | PMID:31228294 PMID31228294 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31228294/
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