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MYP_062242
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Basic Information
ENF (T-20)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Anti-Pneumovirus ▸ Anti-RSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Standard
36 amino acids
C202H298N50O64
Standard
Sequence
YTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWF
Physicochemical Analysis
4450.82 Da
4.30
-5.14
-5.41
-0.1427
-0.88
0.46
-0.05
62.65
89.44
0.1389
17990.00
17990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1894.02
-14.96
63.0
60.0
150.0
316.0
9.0
42.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0213975 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
R3A
6731.67±1082.18
IC50
PMID30716118 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30716118/
RECORD: Rec_0217467 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
Enfuvirtide
11676
Structure & Mods
branched peptide architecture [Branched]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Fusion inhibitor
293T
0.222 μM
IC50
PaperTrimeric, coiled-coil extension on peptide fusion inhibitor of HIV-1 influences selection of resistance pathways. PMID22235115 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22235115/
RECORD: Rec_0218525 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
inhibition of peptide against cell-cell fusion between H9/HIV-1 IIIB cells and MT-2 cells
0.091±0.0012 μM
IC50
Mammalian: 2.8 h; Yeast: 10 min; E. coli: 2 min
PaperCreating an Artificial Tail Anchor as a Novel Strategy To Enhance the Potency of Peptide-Based HIV Fusion Inhibitors. | Su S, Zhu Y, Ye S, Qi Q, Xia S, Ma Z, Yu F, Wang Q, Zhang R, Jiang S, Lu L. | J Virol. 2016 Dec 16;91(1):e01445-16. | DOI:10.1128/JVI.01445-16 | PMID:27795416 PMID27795416 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27795416/
RECORD: Rec_0224819 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral
Evidence URLhttps://patents.google.com/patent/US20100261876A1/en PatentUS 2010/0261876 A1
RECORD: Rec_0227933 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-HIV
Anti-viral potency
0.003 μM
EC50
Sprague-Dawey (SD) rats Plasma, in vivo; 5400 s
PMID25594223 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25594223/
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