Peptide Database

Peptide NameENF (T-20)

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2

Antiviral ▸ Anti-HIV

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Anti-Pneumovirus ▸ Anti-RSV

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Standard StatusStandard

Sequence Length36 amino acids

Chemical FormulaC202H298N50O64

DescriptionStandard

        YTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWF
    

Molecular Weight4450.82 Da

Isoelectric Point (pI)4.30

Net Charge (pH 7.0)-5.14

Net Charge (pH 7.4) -5.41

Charge Density (pH 7.0) -0.1427

GRAVY Index-0.88

Hydrophobic Moment 0.46

Boman Index-0.05

Instability Index62.65

Aliphatic Index 89.44

Aromaticity 0.1389

Extinction Coeff. Reduced 17990.00

Extinction Coeff. Oxidized 17990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1894.02

LogP -14.96

H-bond Donors 63.0

H-bond Acceptors 60.0

Rotatable Bonds 150.0

Heavy Atoms 316.0

Ring Count 9.0

Amide Bonds 42.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0084876 VERIFIED: YES

Provenance & Taxonomy

OrganismHuman immunodeficiency virus 1 [Virus]

FamilyEnfuvirtide

Tax ID11676

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Fusion inhibitor

TargetCEM

Activity0.0006 μg/mL

MethodIC50

RECORD: Rec_0095515 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyHR2 fusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-HIV Fusion inhibition

TargetHIV 098-T1249 | CEM4 cells

Activity12.35 μM

MethodIC50

Half-LifeMammalian: 2.8 h; Yeast: 10 min; E. coli: 2 min

PaperDesign of helical, oligomeric HIV-1 fusion inhibitor peptides with potent activity against enfuvirtide-resistant virus. | Dwyer JJ, Wilson KL, Davison DK, Freel SA, Seedorff JE, Wring SA, Tvermoes NA, Matthews TJ, Greenberg ML, Delmedico MK. | Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12772-7. | DOI:10.1073/pnas.0701478104 | PMID:17640899 PMID17640899 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17640899/

RECORD: Rec_0100799 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyFusion inhibitor peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-HIV HIV fusion inhibitor

TargetHIV-1

Half-Life3.8 ± 0.6 h

PaperPubMed-linked source references: PMID:25594223; PMID:25553058; PMID:24966037; PMID:24816213; PMID:24616600; PMID:24500189; PMID:24446896; PMID:24366751 PMID25594223;25553058;24966037;24816213;24616600;24500189;24446896;24366751 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25594223/ PatentUS6475491

RECORD: Rec_0106721 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyHR2 fusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Fusion inhibition

TargetT-20 resistant HIV-1 NL4-3 (WT,I37T,V38A,V38 M,Q40H,N43K,G36S/V38 M,I37T/N43K,V38A/N42T) | TZM-bl cells

Activity0.09018-2.25 μM

MethodIC50

Half-LifeMammalian: 2.8 h; Yeast: 10 min; E. coli: 2 min

PaperStructural and Functional Characterization of Membrane Fusion Inhibitors with Extremely Potent Activity against Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus. | Chong H, Zhu Y, Yu D, He Y. | J Virol. 2018 Sep 26;92(20):e01088-18. | DOI:10.1128/JVI.01088-18 | PMID:30089693 PMID30089693 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30089693/

RECORD: Rec_0113269 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyHR2 fusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Fusion inhibition

TargetHIV-1N43D | HeLa cells

Activity0.049±0.01 μM

MethodEC50

Half-LifeMammalian: 2.8 h; Yeast: 10 min; E. coli: 2 min

PaperDesign of peptide-based inhibitors for human immunodeficiency virus type 1 strains resistant to T-20. | Izumi K, Kodama E, Shimura K, Sakagami Y, Watanabe K, Ito S, Watabe T, Terakawa Y, Nishikawa H, Sarafianos SG, Kitaura K, Oishi S, Fujii N, Matsuoka M. | J Biol Chem. 2009 Feb 20;284(8):4914-20. | DOI:10.1074/jbc.M807169200 | PMID:19073606 PMID19073606 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19073606/

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