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MYP_062195
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Basic Information
Temporin-MT3
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
13 amino acids
C68H116N14O15
Standard
Sequence
FLPIVGKLLSGLL
Physicochemical Analysis
1369.73 Da
8.75
0.76
0.55
0.0584
1.80
0.44
0.64
-2.08
202.31
0.0769
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
449.98
0.28
15.0
16.0
44.0
97.0
2.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0137078 VERIFIED: YES
Provenance & Taxonomy
Lithobates pipiens [Animal]
Temporin
8404
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Staphylococcus aureus ATCC 25923
8 μM
MIC
PaperPeptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens. PMID10651828 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10651828/
RECORD: Rec_0140160 VERIFIED: YES
Provenance & Taxonomy
Lithobates pipiens [Animal]
Temporin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Hemolytic Cytolytic
Erythrocytes
75.0 μM
HC50
PaperJ.M. Conlon et al. / Peptides 28 (2007) 1268-1274. Peptide defenses of the Cascades frog Rana cascadae: implications for the evolutionary history of frogs of the Amerana species group PMID17451843 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17451843/
RECORD: Rec_0161072 VERIFIED: YES
Provenance & Taxonomy
Amolops loloensis [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli
PaperPubMed PMID: 17000029 PMID17000029 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17000029/
RECORD: Rec_0173009 VERIFIED: YES
Provenance & Taxonomy
Rana pipiens [Animal]
Temporin
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
110 μM
MIC
PMID10651828;17451843 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10651828/
RECORD: Rec_0196607 VERIFIED: YES
Provenance & Taxonomy
Amolops loloensis [Animal]
Amolopin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
8.0 μM
MIC
PaperJ.M. Conlon et al. / Peptides 28 (2007) 1268-1274. Peptide defenses of the Cascades frog Rana cascadae: implications for the evolutionary history of frogs of the Amerana species group PMID17451843 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17451843/
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