Peptide Database

Peptide NameSLAY-screened peptide P4436

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length14 amino acids

Chemical FormulaC60H104N18O17S

DescriptionStandard

        PQVRAVAPLGISCA
    

Molecular Weight1381.64 Da

Isoelectric Point (pI)8.68

Net Charge (pH 7.0)0.95

Net Charge (pH 7.4) 0.88

Charge Density (pH 7.0) 0.0678

GRAVY Index0.87

Hydrophobic Moment 0.35

Boman Index0.28

Instability Index48.64

Aliphatic Index 118.57

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 544.06

LogP -5.82

H-bond Donors 20.0

H-bond Acceptors 19.0

Rotatable Bonds 41.0

Heavy Atoms 96.0

Ring Count 2.0

Amide Bonds 14.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0280419 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/