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MYP_062152
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Basic Information
Cyclotide cter-R
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
31 amino acids
C139H227N35O42S6
Standard
Sequence
GIPCGESCVFIPCTVTALLGCSCKDKVCYKN
Physicochemical Analysis
3252.89 Da
7.76
0.70
0.40
0.0226
0.58
0.25
0.20
24.90
81.61
0.0645
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1215.64
-12.86
47.0
49.0
103.0
222.0
4.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0276535 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Cyclotide
43366
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
N-terminal acetylation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer Cytotoxic
Candida albicans
160 μM
MIC
PaperPubMed PMID 2341998 | PubMed PMID 8270079 | PubMed PMID 10000000 | Nguyen et al., 2016 | Serra et al., 2016 | Gilding et al. 2016 PMID2341998;8270079;10000000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2341998/
RECORD: Rec_0291722 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Cyclotide
43366
Structure & Mods
head-to-tail cyclic cyclotide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anticancer
Pseudomonas aeruginosa
0.625 μM
MIC
PaperDiscovery and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 chain a and cyclotide domains in the fabaceae family
RECORD: Rec_0303984 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Cyclotide
43366
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
N-terminal acetylation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer Cytotoxic Anti-Gram-positive
Staphylococcus aureus
160 μM
MIC
PaperPubMed PMID 2341998 | PubMed PMID 8270079 | PubMed PMID 10000000 | Nguyen et al., 2016 | Serra et al., 2016 | Gilding et al. 2016 PMID2341998;8270079;10000000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2341998/
RECORD: Rec_0304462 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Cyclotide
43366
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
N-terminal acetylation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer Cytotoxic Anti-Gram-negative
Escherichia coli
40 μM
MIC
PaperPubMed PMID 2341998 | PubMed PMID 8270079 | PubMed PMID 10000000 | Nguyen et al., 2016 | Serra et al., 2016 | Gilding et al. 2016 PMID2341998;8270079;10000000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2341998/
RECORD: Rec_0331923 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Cyclotide
43366
Structure & Mods
backbone-cyclized cyclotide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa
0.65 μM
MIC
PMID28669767 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28669767/
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