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MYP_062152
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Basic Information
Cyclotide cter-R
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
31 amino acids
C139H227N35O42S6
Standard
Sequence
GIPCGESCVFIPCTVTALLGCSCKDKVCYKN
Physicochemical Analysis
3252.89 Da
7.76
0.70
0.40
0.0226
0.58
0.25
0.20
24.90
81.61
0.0645
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1215.64
-12.86
47.0
49.0
103.0
222.0
4.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0008292 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Cyclotide
43366
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
N-terminal acetylation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer Cytotoxic Anti-Gram-negative
Pseudomonas aeruginosa
0.625 μM
MIC
PaperPubMed PMID 2341998 | PubMed PMID 8270079 | PubMed PMID 10000000 | Nguyen et al., 2016 | Serra et al., 2016 | Gilding et al. 2016 PMID2341998;8270079;10000000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2341998/
RECORD: Rec_0008748 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Cyclotide
43366
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
N-terminal acetylation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer Cytotoxic
Candida albicans
40 μM
MIC
PaperPubMed PMID 2341998 | PubMed PMID 8270079 | PubMed PMID 10000000 | Nguyen et al., 2016 | Serra et al., 2016 | Gilding et al. 2016 PMID2341998;8270079;10000000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2341998/
RECORD: Rec_0041450 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0071750 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Cyclotide
43366
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
N-terminal acetylation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer Cytotoxic Anti-Gram-positive
Staphylococcus aureus
PaperPubMed PMID 2341998 | PubMed PMID 8270079 | PubMed PMID 10000000 | Nguyen et al., 2016 | Serra et al., 2016 | Gilding et al. 2016 PMID2341998;8270079;10000000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2341998/
RECORD: Rec_0085287 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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