Peptide Database

Peptide NameMT-WQ-IDL

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Standard StatusStandard

Sequence Length31 amino acids

Chemical FormulaC176H279N43O56S

DescriptionStandard

        MTWEEWDKKIEEYTKKIEELIKKSQNQQIDL
    

Molecular Weight3925.42 Da

Isoelectric Point (pI)4.86

Net Charge (pH 7.0)-2.49

Net Charge (pH 7.4) -2.73

Charge Density (pH 7.0) -0.0802

GRAVY Index-1.39

Hydrophobic Moment 0.69

Boman Index-0.28

Instability Index55.25

Aliphatic Index 75.48

Aromaticity 0.0968

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1675.70

LogP -11.29

H-bond Donors 56.0

H-bond Acceptors 55.0

Rotatable Bonds 142.0

Heavy Atoms 276.0

Ring Count 5.0

Amide Bonds 34.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0340307 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyFusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Fusion inhibition

Targetinhibition of peptide against cell-cell fusion between H9/HIV-1 IIIB cells and MT-2 cells

Activity0.0012±0.0002 μM

MethodIC50

Half-LifeMammalian: 30 h; Yeast: >20 h; E. coli: >10 h

PaperCreating an Artificial Tail Anchor as a Novel Strategy To Enhance the Potency of Peptide-Based HIV Fusion Inhibitors. | Su S, Zhu Y, Ye S, Qi Q, Xia S, Ma Z, Yu F, Wang Q, Zhang R, Jiang S, Lu L. | J Virol. 2016 Dec 16;91(1):e01445-16. | DOI:10.1128/JVI.01445-16 | PMID:27795416 PMID27795416 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27795416/

RECORD: Rec_0374778 VERIFIED: YES