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MYP_062083
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Basic Information
CCR5 ECL2 (170-189)
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Standard
20 amino acids
C112H152N28O33S
Standard
Sequence
QKEGLHYTCSSHFPYSQYQF
Physicochemical Analysis
2450.64 Da
6.91
-0.08
-0.40
-0.0038
-1.07
0.20
-0.05
43.39
19.50
0.2500
4470.00
4470.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
998.99
-9.87
35.0
36.0
75.0
174.0
8.0
22.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0267055 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 NL4-3
PMID22403408 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22403408/
RECORD: Rec_0301941 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1 YU2:inhibition of virus infection in TZM-bl cells
237±31 μM
IC50
PaperPubMed PMID: 22403408 PMID22403408 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22403408/
RECORD: Rec_0302824 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 NL4-3 | TZM-bl cells
600±24 μM
IC50
Mammalian: 0.8 h; Yeast: 10 min; E. coli: >10 h
PaperPeptides from second extracellular loop of C-C chemokine receptor type 5 (CCR5) inhibit diverse strains of HIV-1. | Dogo-Isonagie C, Lam S, Gustchina E, Acharya P, Yang Y, Shahzad-ul-Hussan S, Clore GM, Kwong PD, Bewley CA. | J Biol Chem. 2012 Apr 27;287(18):15076-86. | DOI:10.1074/jbc.M111.332361 | PMID:22403408 PMID22403408 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22403408/
RECORD: Rec_0379672 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1 BaL26:inhibition of virus infection in TZM-bl cells
612±21 μM
IC50
PaperPubMed PMID: 22403408 PMID22403408 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22403408/
RECORD: Rec_0413005 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 BaL26
PMID22403408 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22403408/
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