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MYP_061983
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Basic Information
Alyteserin-2a [G11K, N15K]
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
16 amino acids
C78H145N19O20
Standard
Sequence
ILGKLLSTAAKLLSKL
Physicochemical Analysis
1669.10 Da
10.30
2.76
2.55
0.1723
1.03
0.58
0.28
0.19
183.12
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
638.57
-3.58
23.0
23.0
60.0
117.0
0.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0182128 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Alyteserin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
Human erythrocytes
16 μM
Hemolysis
PMID22965637 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22965637/
RECORD: Rec_0189094 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Alyteserin
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D or modified amino-acid peptide [Mixed]
None
Amidation
k=D-Lys
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PMID22965637 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22965637/
RECORD: Rec_0207896 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Alyteserin
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D or modified amino-acid peptide [Mixed]
None
Amidation
k=D-Lys
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: A549
15 μM
LC50
PMID22965637 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22965637/
RECORD: Rec_0216811 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 50.0%, E 0.0%, T 25.0%, C 25.0% [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Toxic Drug Delivery Vehicle Cell-penetrating peptide Hemolytic
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
RECORD: Rec_0251705 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer Cytotoxic
Human colon adenocarcinoma HT29
28 μM
LC50
PMID22965637 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22965637/
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