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MYP_061963
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Basic Information
LP-40
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
28 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
YTSLIHSLIEESQNQQEKNEQELLELDX
Physicochemical Analysis
0.00 Da
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0119818 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical or ambiguous residue annotation [Modified]
unspecified non-canonical residue at 28
Bio-Activity Profile
Antiviral
HIV-1 JRCSF
PMID30867304;30089693 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30867304/
RECORD: Rec_0133718 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical or ambiguous residue annotation [Modified]
unspecified non-canonical residue at 28
Bio-Activity Profile
Antiviral
HIV-1
PMID30867304;30089693 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30867304/
RECORD: Rec_0176818 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical or ambiguous residue annotation [Modified]
unspecified non-canonical residue at 28
Bio-Activity Profile
Antiviral
HIV-1 HxB2
PMID30867304;30089693 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30867304/
RECORD: Rec_0229286 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical or ambiguous residue annotation [Modified]
Acetylation
Amidation
The 'X' at position 28 is Lys-C16(palmitic acid)
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1 NL4-3 pseudovirus; TZM-bl cells
0.000392±0.000073 μM
IC50
PaperStructural and Functional Characterization of Membrane Fusion Inhibitors with Extremely Potent Activity against Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus. J Virol. 2018 Sep 26;92(20):e01088-18. doi: 10.1128/JVI.01088-18. PMID: 30089693. PMID30089693 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30089693/
RECORD: Rec_0244254 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical or ambiguous residue annotation [Modified]
unspecified non-canonical residue at 28
Bio-Activity Profile
Antiviral
HIV-1 NL4-3 PsV
PMID30867304;30089693 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30867304/
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