Peptide Database

Peptide NameApi88

Function Ontology

Antimicrobial

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC94H152N34O21

DescriptionStandard

        KNNRPVYIPRPRPPHPR
    

Molecular Weight2094.43 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)4.85

Net Charge (pH 7.4) 4.59

Charge Density (pH 7.0) 0.2850

GRAVY Index-2.02

Hydrophobic Moment 0.36

Boman Index-0.60

Instability Index44.93

Aliphatic Index 40.00

Aromaticity 0.0588

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 884.89

LogP -8.26

H-bond Donors 29.0

H-bond Acceptors 27.0

Rotatable Bonds 58.0

Heavy Atoms 149.0

Ring Count 8.0

Amide Bonds 18.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0337821 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

FamilyApidaecin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

C-TermAmidation

Other ModsAPD analysis reveals that this sequence is similar (94.12%) to Api88 P:35%; R: 24%; N: 12%. Chemical modification: N-terminal coupled with N,N,N=,N=-tetramethylguanidino group (Gu); warning: N-terminal ornithine is represented as K; C-terminal amidation. Compared to Api88, the C-terminal residue L was deleted

Bio-Activity Profile

Function

Antimicrobial

TargetEscherichia coli BL21 AI

Activity64 μg/mL

MethodMIC

Half-LifeUnspecified 152 min