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MYP_061773
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Basic Information
Brevinin-1RTa (Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Standard
24 amino acids
C124H207N31O27S2
Standard
Sequence
FLPLLAGVVANFLPQIICKIARKC
Physicochemical Analysis
2628.29 Da
9.50
2.74
2.50
0.1141
1.26
0.77
0.37
23.86
150.42
0.0833
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
915.16
-3.11
32.0
32.0
84.0
184.0
4.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0140289 VERIFIED: YES
Provenance & Taxonomy
Amolops ricketti [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
stereochemistry not specified [Other]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC2592
6.3 μg/mL
MIC
PMID22100518 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22100518/
RECORD: Rec_0147165 VERIFIED: YES
Provenance & Taxonomy
Amolops ricketti [Animal]
Brevinin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Rhodococcus rhodochrous X15
3.1 μg/mL
MIC
PMID22100518 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22100518/
RECORD: Rec_0158562 VERIFIED: YES
Provenance & Taxonomy
Amolops ricketti [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Hemolytic Anti-Gram-negative
Psychrobacter faecalis
12.5 μg/mL
MIC
RECORD: Rec_0166929 VERIFIED: YES
Provenance & Taxonomy
Amolops ricketti [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
2.4 μM
MIC
PaperH. Wang et al. / Peptides 33 (2012) 27-34. Identification and characterization of antimicrobial peptides from skin of Amolops ricketti (Anura: Ranidae) Evidence URLhttps://www.uniprot.org/uniprotkb/D1MIZ4/entry
RECORD: Rec_0186469 VERIFIED: YES
Provenance & Taxonomy
Amolops ricketti [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
stereochemistry not specified [Other]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Psychrobacter faecalis X29
12.5 μg/mL
MIC
PMID22100518 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22100518/
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