Peptide Database

Peptide NameSLAY-screened peptide P1135

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC122H168N32O26S2

DescriptionStandard

        GAYAFHHWLFSYLVYMRRMN
    

Molecular Weight2562.97 Da

Isoelectric Point (pI)9.70

Net Charge (pH 7.0)1.93

Net Charge (pH 7.4) 1.62

Charge Density (pH 7.0) 0.0966

GRAVY Index-0.01

Hydrophobic Moment 0.36

Boman Index0.17

Instability Index64.89

Aliphatic Index 63.50

Aromaticity 0.3000

Extinction Coeff. Reduced 9970.00

Extinction Coeff. Oxidized 9970.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 937.18

LogP -3.08

H-bond Donors 35.0

H-bond Acceptors 32.0

Rotatable Bonds 77.0

Heavy Atoms 182.0

Ring Count 9.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0389379 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/