Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length405 amino acids

Chemical FormulaC1964H3036N524O555S14

DescriptionStandard

        MGGPLAVGAECTIAPDFLLMPPSAPPHLRGAPAGCLAPRGSWGAQGIAVLEQELAQLKLPDISGDFRIRHVGKVHYEISSLDLRSFHLPYSRISLVPSVGLQVSISNAFAEVDGNWRVKLRDHGSFDLKVENVYIKINLQLGSDASGKPTADTSDCSTRISKVRVHFSGKFGYLRCLPCPQVCQIVVKSVRSELQPYLRTLPGTDGGFPGLWDGRVPPPSALLLHLSPSSQGEFFSLAHRSAVPFAPLPLAFPPDHDRMVYFGASSYFFNTAGRAYHSAGALVFEITDSMIPKGVEFHLNTTTFSAFIPQLERMYPDMLMKLRLSAPSAPFLDIGPEGLSLRPVVDIQAYAILPNSSLAPLFLLSLVSSGTACGGEGGPGWAAPGANPAQAAAVPGELFQEGSWG
    

Molecular Weight43317.20 Da

Isoelectric Point (pI)6.59

Net Charge (pH 7.0)-1.57

Net Charge (pH 7.4) -2.51

Charge Density (pH 7.0) -0.0039

GRAVY Index0.08

Hydrophobic Moment 0.66

Boman Index0.16

Instability Index44.19

Aliphatic Index 89.63

Aromaticity 0.0914

Extinction Coeff. Reduced 42400.00

Extinction Coeff. Oxidized 42775.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0198164 VERIFIED: NO

Provenance & Taxonomy

OrganismAthene cunicularia (Burrowing owl) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria