Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length443 amino acids

Chemical FormulaC2224H3479N587O621S12

DescriptionStandard

        TNPGFAVRITQAGLDYAHQLGVKVLEKELAQLKLPDISGDFRIRRVGKVRYNISRGAPPAFDLPYSQISLVPGVGLRVSISNAFAEVDGNWRVKMHFIRDDGSFELKVENIYVKIDLKLGSNAAGKPTIDTSDCSTRISNVQVHFYGRFGWLYNLFRGAIESPFRRSLEGKVCENVVSSVRSELQPYLQTLPVTARIDAMAGINYSLVAPPTATARSLDVDLKGEFFSLAHRSAVPFPPPALALPPDHDRMVYFGASSYFFNTASFAYHAAGALVFEITDSMIPKDVEFHLKTSTFSAFVPQLEMMYPDMLMKLRLSTPSAPFLNIGPEGLSLRPVVDIQAYAILPNSSLAPLFLLSLTGNVSAVVDVKSSHIVGSLKVGRMKLSLKHSDVGTFQVRTLQSIMNIYASSILLPRLNGPVPAPRFLFFPQNFLLLGADVSYQPQ
    

Molecular Weight48760.75 Da

Isoelectric Point (pI)9.22

Net Charge (pH 7.0)7.19

Net Charge (pH 7.4) 6.43

Charge Density (pH 7.0) 0.0162

GRAVY Index0.10

Hydrophobic Moment 0.62

Boman Index0.12

Instability Index42.80

Aliphatic Index 97.27

Aromaticity 0.1016

Extinction Coeff. Reduced 33350.00

Extinction Coeff. Oxidized 33475.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0294167 VERIFIED: NO

Provenance & Taxonomy

OrganismEgretta garzetta [Animal]

FamilyBPI/LBP

Tax ID188379

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria