Peptide Database

Peptide NameInsulin-like growth factor II

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Cardiovascular

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Hormonal / Endocrine ▸ Hormone peptide

Metabolic

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length67 amino acids

Chemical FormulaC316H493N91O102S6

DescriptionStandard

        AYGPGETLCGGELVDTLQFVCSDRGFYFSRPSSRANRRSRGIVEECCFRSCDLALLETYCATPAKSE
    

Molecular Weight7391.23 Da

Isoelectric Point (pI)5.35

Net Charge (pH 7.0)-1.24

Net Charge (pH 7.4) -1.54

Charge Density (pH 7.0) -0.0185

GRAVY Index-0.27

Hydrophobic Moment 0.77

Boman Index-0.07

Instability Index69.93

Aliphatic Index 61.19

Aromaticity 0.1045

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4845.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3121.97

LogP -37.32

H-bond Donors 118.0

H-bond Acceptors 107.0

Rotatable Bonds 239.0

Heavy Atoms 515.0

Ring Count 10.0

Amide Bonds 68.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0023758 VERIFIED: NO

Provenance & Taxonomy

OrganismMus musculus [Animal]

FamilyInsulin-like growth factor

Tax ID10090

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide9-47; 21-60; 46-51

Bio-Activity Profile

Function

Anticancer Cytotoxic Hormone Endocrine Cardiovascular Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation ACE inhibitory

Targetglucose metabolism in adipose tissue

Half-LifeMammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0026076 VERIFIED: YES

Provenance & Taxonomy

OrganismMus musculus [Animal]

FamilyInsulin-like growth factor

Tax ID10090

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide9-47; 21-60; 46-51

Bio-Activity Profile

Function

Anticancer Cytotoxic Hormone Endocrine Cardiovascular Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation ACE inhibitory

Half-LifeMammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0148401 VERIFIED: NO

Provenance & Taxonomy

OrganismMus musculus [Animal]

FamilyInsulin

Tax ID10090

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hormone Metabolic