‹ ›
MYP_061429
← PREVIOUS NEXT → BACK
Basic Information
Lacticin 3147 A1 (LtnA1; Bacteriocin; Preclinical)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Reproductive biology ▸ Contraceptive activity ▸ Spermicidal
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
30 amino acids
C148H209N39O46S5
Standard
Sequence
CSTNTFSLSDYWGNNGAWCTLTHECMAWCK
Physicochemical Analysis
3430.80 Da
5.32
-1.19
-1.51
-0.0397
-0.29
0.27
0.11
28.85
32.67
0.1667
17990.00
18240.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1375.00
-15.75
53.0
51.0
104.0
238.0
9.0
32.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0264392 VERIFIED: YES
Provenance & Taxonomy
Lactococcus lactis subsp. lactis [Bacterium]
Bacteriocin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Lactococcus lactis strain AM2
Evidence URLhttps://camp.bicnirrh.res.in/seqDisp.php?id=CAMPSQ3887
RECORD: Rec_0330335 VERIFIED: NO
Provenance & Taxonomy
Lactococcus lactis [Bacterium]; Bacteria [Bacterium]
Bacteriocin
1358; 2
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0380652 VERIFIED: YES
Provenance & Taxonomy
Lactococcus lactis [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0384745 VERIFIED: YES
Provenance & Taxonomy
Lactococcus lactis subsp. lactis [Bacterium]
Bacteriocin
Structure & Mods
thioether-constrained cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
None
None
There are two 2,3-dehydrobutyrines (T3; T5), one 2,3-didehydroalanine (S7), two Lanthionines (C1-S2; S9-C19) and two Beta-methyllanthionines (T20-C25; T22-C29)
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Leuconostoc
PaperPubMed PMID: 10971756 | PubMed PMID: 15023056 | PubMed PMID: 10608807 PMID10971756;15023056;10608807 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10971756/
RECORD: Rec_0391176 VERIFIED: YES
Provenance & Taxonomy
Lactococcus lactis [Bacterium]
Bacteriocin
1358
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
produced by the food-grade organism Lactococcus lactis
Bio-Activity Profile
Antimicrobial Spermicidal
Enterococcus faecalis
1.9-3.8 μg/mL
MIC
PaperStructural characterization of lacticin 3147, a two-peptide lantibiotic with synergistic activity.
FIRST PREV 1 2 3 NEXT LAST
Showing 5 records on this page · Page 2 of 3