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MYP_061429
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Basic Information
Lacticin 3147 A1 (LtnA1; Bacteriocin; Preclinical)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Reproductive biology ▸ Contraceptive activity ▸ Spermicidal
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
30 amino acids
C148H209N39O46S5
Standard
Sequence
CSTNTFSLSDYWGNNGAWCTLTHECMAWCK
Physicochemical Analysis
3430.80 Da
5.32
-1.19
-1.51
-0.0397
-0.29
0.27
0.11
28.85
32.67
0.1667
17990.00
18240.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1375.00
-15.75
53.0
51.0
104.0
238.0
9.0
32.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0038154 VERIFIED: YES
Provenance & Taxonomy
Lactococcus lactis subsp. lactis [Bacterium]
Bacteriocin
Structure & Mods
thioether-constrained cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
None
None
There are two 2,3-dehydrobutyrines (T3; T5), one 2,3-didehydroalanine (S7), two Lanthionines (C1-S2; S9-C19) and two Beta-methyllanthionines (T20-C25; T22-C29)
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Lactococcus
PaperPubMed PMID: 10971756 | PubMed PMID: 15023056 | PubMed PMID: 10608807 PMID10971756;15023056;10608807 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10971756/
RECORD: Rec_0089215 VERIFIED: YES
Provenance & Taxonomy
Lactococcus lactis subsp. lactis [Bacterium]
Bacteriocin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Lactococcus lactis strain HP
Evidence URLhttps://camp.bicnirrh.res.in/seqDisp.php?id=CAMPSQ3887
RECORD: Rec_0094400 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAntiCP 2.0: an updated model for predicting anticancer peptides (benchmark provenance; exact sequence-level experiment paper unresolved here) | https://pubmed.ncbi.nlm.nih.gov/32770192/
RECORD: Rec_0144766 VERIFIED: YES
Provenance & Taxonomy
Lactococcus lactis subsp. lactis [Bacterium]
Bacteriocin
Structure & Mods
thioether-constrained cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
None
None
There are two 2,3-dehydrobutyrines (T3; T5), one 2,3-didehydroalanine (S7), two Lanthionines (C1-S2; S9-C19) and two Beta-methyllanthionines (T20-C25; T22-C29)
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Enterococcus
PaperPubMed PMID: 10971756 | PubMed PMID: 15023056 | PubMed PMID: 10608807 PMID10971756;15023056;10608807 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10971756/
RECORD: Rec_0161644 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Toxic Anti-Gram-positive Cytotoxic
PaperCAMP: Collection of sequences and structures of antimicrobial peptides PMID24265220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24265220/
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