Peptide Database

Peptide NameProgonadoliberin-1

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Reproductive neuropeptide

Reproductive biology ▸ Reproductive modulation

Standard StatusStandard

Sequence Length63 amino acids

Chemical FormulaC320H498N96O101S2

DescriptionStandard

        QHWSYGLRPGGKRNAERLGDSFQEMDKEVDQLAEPQHLECTVHWPRSPLRDLRGVLESLIEEE
    

Molecular Weight7370.09 Da

Isoelectric Point (pI)5.09

Net Charge (pH 7.0)-4.96

Net Charge (pH 7.4) -5.35

Charge Density (pH 7.0) -0.0787

GRAVY Index-1.02

Hydrophobic Moment 0.78

Boman Index-0.21

Instability Index79.98

Aliphatic Index 72.70

Aromaticity 0.0635

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3195.15

LogP -30.91

H-bond Donors 110.0

H-bond Acceptors 101.0

Rotatable Bonds 246.0

Heavy Atoms 519.0

Ring Count 13.0

Amide Bonds 67.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0076679 VERIFIED: NO

Provenance & Taxonomy

OrganismMesocricetus auratus [Animal]

FamilyProgonadoliberin

Tax ID10036

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermPyroglutamate

Other Mods10:Glycine amide

Bio-Activity Profile

Function

Hormone Endocrine Reproductive regulator

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour

RECORD: Rec_0272681 VERIFIED: NO

Provenance & Taxonomy

OrganismMesocricetus auratus [Animal]

FamilyGnRH

Tax ID10036

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermPyroglutamate

Other ModsGly10 Amidation

Bio-Activity Profile

Function

Hormone Reproductive neuropeptide

RECORD: Rec_0370825 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/