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MYP_061417
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Basic Information
D5C1
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Retrovirus ▸ Anti-Lentivirus ▸ Anti-FIV
Antiviral ▸ Antiviral mechanism ▸ Viral release inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral release inhibition ▸ Release inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
37 amino acids
C191H355N69O38
Standard
Sequence
KRKRAVKRVGRRLKKLARKIARLGVAKLAGLRAVKLF
Physicochemical Analysis
4226.30 Da
12.00
15.75
15.54
0.4257
-0.29
1.05
-0.37
41.52
121.35
0.0270
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1814.28
-13.81
70.0
54.0
157.0
298.0
1.0
36.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0013989 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Feline immunodeficiency virus(FIV-Petaluma):inhibition of reverse transcriptase activity in CrFK cells
3.38 μM
IC50
PaperPubMed PMID: 12208971 PMID12208971 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12208971/
RECORD: Rec_0072824 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-FIV Release inhibition
Feline immunodeficiency virus(FIV-Petaluma) | CrFK cells
3.38 μM
IC50
Mammalian: 1.3 h; Yeast: 3 min; E. coli: 2 min
PaperInhibitory activity of synthetic peptide antibiotics on feline immunodeficiency virus infectivity in vitro. | Ma J, Kennedy-Stoskopf S, Jaynes JM, Thurmond LM, Tompkins WA. | J Virol. 2002 Oct;76(19):9952-61. | DOI:10.1128/jvi.76.19.9952-9961.2002 | PMID:12208971 PMID12208971 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12208971/
RECORD: Rec_0147071 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 12208971 PMID12208971 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12208971/
RECORD: Rec_0209563 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Release inhibitor
Feline immunodeficiency virus (Release); CrFK
3.38 μM
RT-PCR
PaperInhibitory activity of synthetic peptide antibiotics on feline immunodeficiency virus infectivity in vitro. | Ma J, Kennedy-Stoskopf S, Jaynes JM, Thurmond LM, Tompkins WA. | J Virol. 2002 | PMID:12208971 PMID12208971 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12208971/
RECORD: Rec_0328188 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PaperPubMed PMID: 12208971 PMID12208971 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12208971/
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