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MYP_061324
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Basic Information
Magainin-1 (Magainin I; chain of Magainins; Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
23 amino acids
C112H177N29O28S
Standard
Sequence
GIGKFLHSAGKFGKAFVGEIMKS
Physicochemical Analysis
2409.85 Da
10.00
2.85
2.59
0.1237
0.22
0.64
0.23
-3.80
72.17
0.1304
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
914.04
-7.13
32.0
33.0
84.0
170.0
4.0
22.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0364394 VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]
Magainin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
PaperK. Matsuzaki et al. / Biochimica et Biophysica Acta 1327 (1997) 119-130. Interactions of an antimicrobial peptide, magainin 2, with outer and inner membranes of Gram-negative bacteria Evidence URLhttps://www.uniprot.org/uniprotkb/P11006/entry
RECORD: Rec_0365100 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Magainin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Human erythrocytes
80 μg/mL
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/10795591/ PMID10795591 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10795591/
RECORD: Rec_0412545 VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]
Magainin
8355
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral
coli ML-35p, Escherichia coli mcr 106, Escherichia coli BAS 849, S. typhimurium 14028S, S. typhimurium 7953S, Klebsiella pneumoniae 2270, Pseudomonas aeruginosa SBI-N, Pseudomonas aeruginosa MR2123, and Pseudomonas aeruginosa MR3007
0.4-1.8 μg/mL
MIC
PaperMagainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor
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