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MYP_061324
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Basic Information
Magainin-1 (Magainin I; chain of Magainins; Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
23 amino acids
C112H177N29O28S
Standard
Sequence
GIGKFLHSAGKFGKAFVGEIMKS
Physicochemical Analysis
2409.85 Da
10.00
2.85
2.59
0.1237
0.22
0.64
0.23
-3.80
72.17
0.1304
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
914.04
-7.13
32.0
33.0
84.0
170.0
4.0
22.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0254937 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Magainin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperZasloff M.. Magainins, a class of antimicrobial peptides from Xenopus Skin: Isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc. Natl Acad. Sci. USA, 84, 5449-5453, 1987.
RECORD: Rec_0283676 VERIFIED: NO
Provenance & Taxonomy
Xenopus laevis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperPatent US 6872705 B2 Evidence URLhttps://patents.google.com/patent/US6872705B2/en PatentUS 6872705 B2
RECORD: Rec_0304699 VERIFIED: NO
Provenance & Taxonomy
African clawed [Animal]
Magainin
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0319085 VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]
Magainin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PMID3299384 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3299384/
RECORD: Rec_0357833 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 17.4%, E 0.0%, T 47.8%, C 34.8% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antiviral Toxic Antimicrobial Hemolytic Anti-Gram-positive Anti-Gram-negative
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
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