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MYP_061324
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Basic Information
Magainin-1 (Magainin I; chain of Magainins; Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
23 amino acids
C112H177N29O28S
Standard
Sequence
GIGKFLHSAGKFGKAFVGEIMKS
Physicochemical Analysis
2409.85 Da
10.00
2.85
2.59
0.1237
0.22
0.64
0.23
-3.80
72.17
0.1304
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
914.04
-7.13
32.0
33.0
84.0
170.0
4.0
22.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0019967 VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]
Magainin
8355
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperPubMed PMID: 3299384 PMID3299384 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3299384/
RECORD: Rec_0034377 VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]
Magainin
8355
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HSV Entry inhibition
Herpes simplex virus type 2 (HSV-2) | Vero cells
33.2 μM
EC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperAntiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus. | Albiol Matanic VC, Castilla V. | Int J Antimicrob Agents. 2004 Apr;23(4):382-9. | DOI:10.1016/j.ijantimicag.2003.07.022 | PMID:15081088 PMID15081088 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15081088/
RECORD: Rec_0035611 VERIFIED: NO
Provenance & Taxonomy
Xenopus laevis [Animal]; Xenopus petersii [Animal]; Xenopus gilli [Animal]
Magainin
8355
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antiparasitic
RECORD: Rec_0050071 VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]
Magainin
8355;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Replication inhibitor
Herpes simplex virus 1 (Protein synthesis); Vero
36.59 μM
EC50
PaperAntiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus. | Albiol Matanic VC, Castilla V. | Int J Antimicrob Agents. 2004 | PMID:15081088 PMID15081088 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15081088/
RECORD: Rec_0085360 VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]
Magainin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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