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MYP_061282
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Basic Information
Cap-HSLP
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
11 amino acids
C66H96N22O12
Standard
Sequence
WWVAAFAARRR
Physicochemical Analysis
1389.61 Da
12.00
2.76
2.56
0.2509
-0.10
0.13
-0.11
105.52
62.73
0.2727
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
571.60
-2.54
23.0
15.0
40.0
100.0
5.0
10.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0393242 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Caproylamide
Amidation
The Ⓧ (position: 4 and 8) in sequence indicates (S)-2-(4'-pentenyl)-alanine. Ⓧ (4) and Ⓧ (8) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Antimicrobial Antibacterial
Enterococcus faecalis ATCC 29212
0.63 μM
IC50
PaperZachary B Jenner, Christopher M Crittenden, Martín Gonzalez, Jennifer S Brodbelt, Kerry A Bruns. Hydrocarbon-stapled lipopeptides exhibit selective antimicrobial activity. Biopolymers. 2017 May;108(3). PMID28073163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28073163/
RECORD: Rec_0417410 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Caproylamide
Amidation
The Ⓧ (position: 4 and 8) in sequence indicates (S)-2-(4'-pentenyl)-alanine. Ⓧ (4) and Ⓧ (8) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Antimicrobial Antibacterial
Enterococcus faecalis ATCC 29212
1.25 μM
MIC
PaperZachary B Jenner, Christopher M Crittenden, Martín Gonzalez, Jennifer S Brodbelt, Kerry A Bruns. Hydrocarbon-stapled lipopeptides exhibit selective antimicrobial activity. Biopolymers. 2017 May;108(3). PMID28073163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28073163/
RECORD: Rec_0425986 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Caproylamide
Amidation
The Ⓧ (position: 4 and 8) in sequence indicates (S)-2-(4'-pentenyl)-alanine. Ⓧ (4) and Ⓧ (8) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli ATCC 700926
>20 μM
MIC
PaperZachary B Jenner, Christopher M Crittenden, Martín Gonzalez, Jennifer S Brodbelt, Kerry A Bruns. Hydrocarbon-stapled lipopeptides exhibit selective antimicrobial activity. Biopolymers. 2017 May;108(3). PMID28073163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28073163/
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