MYP_061282
Cap-HSLP
Antimicrobial
Antimicrobial
▸
Antibacterial
Antimicrobial
▸
Antifungal
Toxicity / Safety
▸
Blood cell toxicity
▸
Hemolysis
▸
Hemolytic
Standard
11 amino acids
C66H96N22O12
Standard
WWVAAFAARRR
1389.61 Da
12.00
2.76
2.56
0.2509
-0.10
0.13
-0.11
105.52
62.73
0.2727
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
571.60
-2.54
23.0
15.0
40.0
100.0
5.0
10.0
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0238641
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Caproylamide
Amidation
The Ⓧ (position: 4 and 8) in sequence indicates (S)-2-(4'-pentenyl)-alanine. Ⓧ (4) and Ⓧ (8) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Antifungal
Candida albicans 002 ATCC 64385
>20 μM
IC50
RECORD: Rec_0242344
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Caproylamide
Amidation
The Ⓧ (position: 4 and 8) in sequence indicates (S)-2-(4'-pentenyl)-alanine. Ⓧ (4) and Ⓧ (8) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Antifungal
Candida albicans 004 ATCC MYA-2876
>20 μM
IC50
RECORD: Rec_0285152
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Caproylamide
Amidation
The Ⓧ (position: 4 and 8) in sequence indicates (S)-2-(4'-pentenyl)-alanine. Ⓧ (4) and Ⓧ (8) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Antifungal
Candida albicans 004 ATCC MYA-2876
>20 μM
MIC
RECORD: Rec_0337341
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Caproylamide
Amidation
The Ⓧ (position: 4 and 8) in sequence indicates (S)-2-(4'-pentenyl)-alanine. Ⓧ (4) and Ⓧ (8) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Hemolytic
human red blood cells
4.49 μM
HC50
RECORD: Rec_0338213
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Caproylamide
Amidation
The Ⓧ (position: 4 and 8) in sequence indicates (S)-2-(4'-pentenyl)-alanine. Ⓧ (4) and Ⓧ (8) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Antimicrobial
Antibacterial
Staphylococcus aureus ATCC 6538
5.00 μM
MIC
Showing 5 records on this page · Page 2 of 3