Peptide Database

Peptide NameC3a

Function Ontology

Immunology ▸ Immune cell migration ▸ Chemotactic peptide

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Neurological / Signaling ▸ Signaling peptide

Standard StatusStandard

Sequence Length78 amino acids

Chemical FormulaC383H642N132O113S10

DescriptionStandard

        SVQLMERRMDKAGQYTDKGLRKCCEDGMRDIPMRYSCQRRARLITQGENCIKAFIDCCNHITKLREQHRRDHVLGLAR
    

Molecular Weight9224.66 Da

Isoelectric Point (pI)9.45

Net Charge (pH 7.0)6.67

Net Charge (pH 7.4) 6.21

Charge Density (pH 7.0) 0.0856

GRAVY Index-0.85

Hydrophobic Moment 0.69

Boman Index-0.35

Instability Index36.59

Aliphatic Index 67.56

Aromaticity 0.0385

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4070.41

LogP -44.77

H-bond Donors 152.0

H-bond Acceptors 133.0

Rotatable Bonds 324.0

Heavy Atoms 638.0

Ring Count 7.0

Amide Bonds 84.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0027332 VERIFIED: NO

Provenance & Taxonomy

OrganismMus musculus [Animal]

FamilyGtoPdb endogenous peptide ligand

Tax ID10090

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidereported in GtoPdb PTM annotation

Other ModsThere are 3 disulfide bonds formed between Cysteine residues at positions 23 and 50, 24 and 57, 37 and 58.

Bio-Activity Profile

Function

Chemotactic Immunomodulatory Signaling peptide

TargetC3a receptor (Mouse); C5a1 receptor (Mouse)