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MYP_061185
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Basic Information
HRA1
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
43 amino acids
C204H353N59O64
Standard
Sequence
TIRLESEVTAIKNALKKTNEAVSTLGNGVRVLATAVRELKDFV
Physicochemical Analysis
4656.34 Da
9.52
1.41
1.20
0.0327
0.05
0.76
-0.01
0.11
115.58
0.0233
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2032.68
-21.62
72.0
66.0
162.0
327.0
1.0
45.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0076067 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-MPV Fusion inhibition
Human Metapneumovirus(hMPV) | LLC-MK2 cells
0.177 μM
IC50
Mammalian: 7.2 h; Yeast: >20 h; E. coli: >10 h
PaperIdentification and evaluation of a highly effective fusion inhibitor for human metapneumovirus. | Deffrasnes C, Hamelin ME, Prince GA, Boivin G. | Antimicrob Agents Chemother. 2008 Jan;52(1):279-87. | DOI:10.1128/AAC.00793-07 | PMID:17967906 PMID17967906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17967906/
RECORD: Rec_0109543 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 93.0%, E 0.0%, T 0.0%, C 7.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0135190 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Human Metapneumovirus(hMPV):inhibition of viral infection in LLC-MK2 cells
0.177 μM
IC50
PaperPubMed PMID: 17967906 PMID17967906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17967906/
RECORD: Rec_0258556 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
LLC-MK2 cells at the highest concentrations tested (9 μM)
PaperPubMed PMID: 17967906 PMID17967906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17967906/
RECORD: Rec_0261073 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 17967906 PMID17967906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17967906/
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