MYP_061174
Api88
Antimicrobial
Standard
18 amino acids
C100H163N35O22
Standard
KNNRPVYIPRPRPPHPRL
2207.59 Da
12.00
4.85
4.59
0.2692
-1.69
0.40
-0.50
42.99
59.44
0.0556
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
913.99
-7.73
30.0
28.0
62.0
157.0
8.0
19.0
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0030571
VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Apidaecin
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
APD analysis reveals that this sequence is similar (88.89%) to Apidaecin IB P:33%; R: 22%; N: 11%. Chemical modification: N-terminal coupled with N,N,N=,N=-tetramethylguanidino group (Gu); warning: N-terminal ornithine is represented as K; C-terminal amidation
Bio-Activity Profile
Antimicrobial
Escherichia coli BL21 AI
0.5 μg/mL
MIC
Unspecified 10 min
RECORD: Rec_0071319
VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Apidaecin
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
APD analysis reveals that this sequence is similar (88.89%) to Apidaecin IB P:33%; R: 22%; N: 11%. Chemical modification: N-terminal coupled with N,N,N=,N=-tetramethylguanidino group (Gu); warning: N-terminal ornithine is represented as K; C-terminal amidation
Bio-Activity Profile
Antimicrobial
APi155: A change of the same R to homoR had the MIC of 2 ug/ml. Api161: attaching a C3H7 group to C-terminal amide of Api88
4 μg/mL
MIC
Unspecified 10 min
RECORD: Rec_0095113
VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Apidaecin
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
APD analysis reveals that this sequence is similar (88.89%) to Apidaecin IB P:33%; R: 22%; N: 11%. Chemical modification: N-terminal coupled with N,N,N=,N=-tetramethylguanidino group (Gu); warning: N-terminal ornithine is represented as K; C-terminal amidation
Bio-Activity Profile
Antimicrobial
Api162: attaching a CH3 group to C-terminal amide of Api88
4 μg/mL
MIC
Unspecified 10 min
RECORD: Rec_0290245
VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Apidaecin
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
APD analysis reveals that this sequence is similar (88.89%) to Apidaecin IB P:33%; R: 22%; N: 11%. Chemical modification: N-terminal coupled with N,N,N=,N=-tetramethylguanidino group (Gu); warning: N-terminal ornithine is represented as K; C-terminal amidation
Bio-Activity Profile
Antimicrobial
2 μg/mL
MIC
Unspecified 10 min