Peptide Database

Peptide NameSLAY-screened peptide P2772

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC91H157N31O30S4

DescriptionStandard

        SNTSSHGIPMRCMSIMRLASN
    

Molecular Weight2293.67 Da

Isoelectric Point (pI)10.35

Net Charge (pH 7.0)1.54

Net Charge (pH 7.4) 1.27

Charge Density (pH 7.0) 0.0732

GRAVY Index-0.15

Hydrophobic Moment 0.43

Boman Index-0.03

Instability Index29.98

Aliphatic Index 60.48

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 996.57

LogP -14.84

H-bond Donors 37.0

H-bond Acceptors 37.0

Rotatable Bonds 76.0

Heavy Atoms 156.0

Ring Count 2.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0317239 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/