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MYP_061134
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Basic Information
Lfcin1 ( LfcinB17-31)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Binding / Molecular interaction ▸ Binding activity
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
15 amino acids
C91H144N30O17S2
Standard
Sequence
FKCRRWQWRMKKLGA
Physicochemical Analysis
1994.44 Da
11.74
5.75
5.53
0.3831
-1.21
0.57
-0.47
64.37
32.67
0.2000
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
809.15
-4.30
32.0
25.0
68.0
140.0
5.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0320565 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
24 μM
MIC
PaperPubMed PMID: 11095180 PMID11095180 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11095180/
RECORD: Rec_0320948 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
7.5% hemolysis of mouse RBC at 256??g/ml
Hemolysis
PMID28287172;34209722;11095180;30043322 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28287172/
RECORD: Rec_0329149 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
S. pullorum CVCC1802
64 μM
MIC
PMID28287172;34209722;11095180;30043322 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28287172/
RECORD: Rec_0340904 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans S5314
6.25 μg/mL
MIC
PMID34209722 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34209722/
RECORD: Rec_0346917 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Lactoferricin
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
ACE inhibitory Antihypertensive
Angiotensin-converting enzyme (ACE)
IC50
PaperAntihypertensive Properties of Lactoferricin β-Derived Peptides | Ruiz-Gimenez, P. et al. | DOI: 10.1021/jf100899u Evidence URLhttps://www.uniprot.org/uniprotkb/P24627/entry
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