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MYP_061134
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Basic Information
Lfcin1 ( LfcinB17-31)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Binding / Molecular interaction ▸ Binding activity
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
15 amino acids
C91H144N30O17S2
Standard
Sequence
FKCRRWQWRMKKLGA
Physicochemical Analysis
1994.44 Da
11.74
5.75
5.53
0.3831
-1.21
0.57
-0.47
64.37
32.67
0.2000
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
809.15
-4.30
32.0
25.0
68.0
140.0
5.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0062766 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Acinetobacter baumannii ATCC 19606
4 μg/mL
MIC
PMID30043322 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30043322/
RECORD: Rec_0070866 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli CVCC1515
16 μM
MIC
PMID28287172;34209722;11095180;30043322 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28287172/
RECORD: Rec_0081481 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans S5314
12.5 μg/mL
MIC
PMID34209722 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34209722/
RECORD: Rec_0084781 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa CICC21630
64 μM
MIC
PMID28287172;34209722;11095180;30043322 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28287172/
RECORD: Rec_0107632 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Lactoferricin
9913.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Antimicrobial
SH-SY-5Y2 (brain tumor)
60 μM
IC50
PaperThe antimicrobial peptide, lactoferricin B, is cytotoxic to neuroblastoma cells in vitro and inhibits xenograft growth in vivo | https://pubmed.ncbi.nlm.nih.gov/16572423/ PMID16572423 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16572423/
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