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MYP_061077
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Basic Information
Com7
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
8 amino acids
C55H77N19O9S2
Standard
Sequence
CRRWWRFC
Physicochemical Analysis
1212.45 Da
10.41
2.74
2.51
0.3425
-0.94
0.92
-0.53
151.95
0.00
0.3750
11000.00
11125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
484.30
-1.87
22.0
14.0
35.0
85.0
5.0
7.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0131347 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Lactoferricin
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Amidation
1-8
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus
0.9 μM
LD99
Human Serum: Resistant with ~50% intact peptide left after an incubation time of 6.5 h
PaperNguyen LT, Chau JK, Perry NA, de Boer L, Zaat SA, Vogel HJ. Serum stabilities of short tryptophan- and arginine-rich antimicrobial peptide analogs. PLoS One. 2010 Sep 10;5(9):e12684. PMID:20844765 https://pubmed.ncbi.nlm.nih.gov/20844765/ PMID20844765 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20844765/
RECORD: Rec_0132134 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Lactoferricin
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
1-8
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli
30 μM
LD99
Human Serum: Resistant with ~50% intact peptide left after an incubation time of 6.5 h
PaperNguyen LT, Chau JK, Perry NA, de Boer L, Zaat SA, Vogel HJ. Serum stabilities of short tryptophan- and arginine-rich antimicrobial peptide analogs. PLoS One. 2010 Sep 10;5(9):e12684. PMID:20844765 https://pubmed.ncbi.nlm.nih.gov/20844765/ PMID20844765 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20844765/
RECORD: Rec_0159915 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Bacillus subtilis ATCC 6633 LC
0.9 μM
PMID20844765 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20844765/
RECORD: Rec_0162505 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
1-8
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli
30 μM
LD99.99
Human serum, in vitro; 23400 s
PaperSerum stabilities of short tryptophan- and arginine-rich antimicrobial peptide analogs PMID20844765 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20844765/
RECORD: Rec_0165921 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus 42D LC
15 μM
PMID20844765 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20844765/
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