‹ ›
MYP_060776
← PREVIOUS NEXT → BACK
Basic Information
N24
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Standard
24 amino acids
C112H191N35O37
Standard
Sequence
KQNAANILRLKESIAATNEAVHEV
Physicochemical Analysis
2619.93 Da
6.76
-0.15
-0.41
-0.0061
-0.31
0.44
-0.06
52.02
110.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1199.96
-13.51
40.0
38.0
91.0
184.0
1.0
27.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0127338 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Contains non-standard symbols/residues: -.
Bio-Activity Profile
Antiviral Anti-NDV Fusion inhibition
Newcastle disease virus (NDV) | NDV-infected cells
0.0225 μM
IC50
Mammalian: 1.3 h; Yeast: 3 min; E. coli: 2 min
PaperMode of action of two inhibitory peptides from heptad repeat domains of the fusion protein of Newcastle disease virus. | San Román K, Villar E, Muñoz-Barroso I. | Int J Biochem Cell Biol. 2002 Oct;34(10):1207-20. | DOI:10.1016/s1357-2725(02)00045-6 | PMID:12127571 PMID12127571 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12127571/
RECORD: Rec_0233314 VERIFIED: YES
Provenance & Taxonomy
Avian orthoavulavirus 1 [Virus]
Heptad repeat peptide
2560319;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Fusion inhibitor
Newcastle disease virus (Fusion); Cos-7
0.0225 μM
Syncytia assay
PaperMode of action of two inhibitory peptides from heptad repeat domains of the fusion protein of Newcastle disease virus. | San Roman K, Villar E, Munoz-Barroso I. | Int J Biochem Cell Biol. 2002 | PMID:12127571 PMID12127571 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12127571/
RECORD: Rec_0233608 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses (https://pubmed.ncbi.nlm.nih.gov/24285301/) PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/