Peptide Database

Peptide NameBig defensin (AiBD)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length122 amino acids

Chemical FormulaC599H954N182O162S11

DescriptionStandard

        MTRPSLVRCYSLFFTALIVMAIICPAWSEEIPKSRKKRAIPIAYVGMAVAPQVFRWLVRAYGAAAVTAAGVTLRRVINRSRSNDNHSCYGNRGWCRSSCRSYEREYRGGNLGVCGSYKCCVT
    

Molecular Weight13649.82 Da

Isoelectric Point (pI)10.01

Net Charge (pH 7.0)13.51

Net Charge (pH 7.4) 13.10

Charge Density (pH 7.0) 0.1107

GRAVY Index-0.02

Hydrophobic Moment 0.77

Boman Index-0.02

Instability Index56.11

Aliphatic Index 78.36

Aromaticity 0.1066

Extinction Coeff. Reduced 26930.00

Extinction Coeff. Oxidized 27430.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 5559.43

LogP -57.59

H-bond Donors 213.0

H-bond Acceptors 188.0

Rotatable Bonds 439.0

Heavy Atoms 954.0

Ring Count 22.0

Amide Bonds 127.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0115685 VERIFIED: YES

Provenance & Taxonomy

OrganismArgopecten irradians [other]

FamilyDefensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Defensin Antifungal Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetGram-negative and Gram-positive bacteria