Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length998 amino acids

Chemical FormulaC4939H7875N1353O1543S36

DescriptionStandard

        MTDLNLDDVQDTSPEKDSFPAIERLNSKDDINQTQHTSNLEDNEPPGEEGSNSQHDGQDLSELRDSDSSVDSIDNIFPNLTIILTGNISAIQFGQENILLQDNAELSRIVPVQTKISKYHISVINMTGLHEDEVNYVDYVGQLVNKNEINAFIFVVQLDQLTDADKMGLEWLQRAFGDNVLQFVMILCTYERKEDCDTMQDDLEKILEKCGRRYHTCSKMMNDRSEMKKLMKKIDRLFYENNQQCYTEELYKTVLRQREGLKDSTFKNTEDETTINKDITEDTTTSESGEKHMPLSQAAPPPPIQSQGTFQPGPPAGLLLEPKLPAPERYDGNPERKVFHHPVSGAEVDNRLLQLTQGTRSVAEFAIEFHTLAAESEWDHQALKAAFHRAVSPELKDELAYRDPSPLIDVAIRLDNPRSMQTSFDTPEMEDRPEPIIPSSKVVAGVQWGIELAVKKAQRQQPDPARTGPEGQTRRALALLESWQGARAELRAWQAGRVEPASRLLSGAGSALVKGGANIKARSLGGAKRKKATLFSTVVDTPYKLPERQYPQHSHLPDKDGLIKAVVKDILELCVTYVESLCYKQELVSKLLYTGSSLLKRKEPPALGSHLMSGRAGRWEQEDAHVLLSALLANSVAQYLKKRSSREFRPEIFRENAEDESLMLLEQMGVGTTGTGNTTENHLKFTEQVSKDDCRRRQVECNKEYEGEKKFLPKTEASLKVCEEMVFCWCALALLTLAPVVTGNNAGVKVRLTQRGLDYATINEYAAIDYSLRSVDITDTSIELGLKGIFYNTPRTQEPRFPSTAVSCTSLNSKMFCVAISAFTINSAFSVFHNTGVFNITITDDMISEKYPDLKLELEVKTVKEPDIQFEPNNVILKIFSTVTAVQSGNRLTQLFILNLESSASVQVSVREDKLVLALNLEKIDVSMNTKTFKFTNLSFLNMAIKDILFPIIKAHLAKDFPLPGLLRSTMVRFINPQVEVLKDYVMIGTDIQFGENT
    

Molecular Weight112050.84 Da

Isoelectric Point (pI)5.27

Net Charge (pH 7.0)-27.86

Net Charge (pH 7.4) -29.50

Charge Density (pH 7.0) -0.0279

GRAVY Index-0.42

Hydrophobic Moment 0.91

Boman Index-0.05

Instability Index45.16

Aliphatic Index 86.07

Aromaticity 0.0681

Extinction Coeff. Reduced 72770.00

Extinction Coeff. Oxidized 73645.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0078805 VERIFIED: NO

Provenance & Taxonomy

OrganismLabeo rohita [Bacterium]

FamilyBPI

Tax ID84645

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence