Peptide Database

Peptide NamedCATH 12-5 (modified from dCATH 12)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC90H135N25O14

DescriptionStandard

        LWKKIYRKWKRW
    

Molecular Weight1791.19 Da

Isoelectric Point (pI)11.22

Net Charge (pH 7.0)5.76

Net Charge (pH 7.4) 5.54

Charge Density (pH 7.0) 0.4796

GRAVY Index-1.69

Hydrophobic Moment 0.95

Boman Index-0.49

Instability Index82.63

Aliphatic Index 65.00

Aromaticity 0.3333

Extinction Coeff. Reduced 17990.00

Extinction Coeff. Oxidized 17990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 678.90

LogP 0.99

H-bond Donors 27.0

H-bond Acceptors 20.0

Rotatable Bonds 59.0

Heavy Atoms 129.0

Ring Count 7.0

Amide Bonds 11.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0377303 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-negative Anti-Gram-positive

TargetResistant Gram-positive bacteria: MRSA CCARM 3089

Activity16 μM

MethodMIC

RECORD: Rec_0386206 VERIFIED: YES