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MYP_060597
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Basic Information
Serum albumin precursor [011-013]
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Regulatory peptide ▸ Biological regulation
Sensory / Food function ▸ Taste-active peptide
Sensory / Food function ▸ Taste-active peptide ▸ Bitter peptide
Standard
3 amino acids
C21H33N3O4
Standard
Sequence
LLF
Physicochemical Analysis
391.50 Da
5.53
-0.24
-0.44
-0.0800
3.47
0.23
1.10
6.67
260.00
0.3333
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
121.52
1.70
4.0
4.0
11.0
28.0
1.0
2.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0233626 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
ACE-inhibitory peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
Spontaneously hypertensive rat (SHR)
20 mmHg
SBP decrease
PaperAntihypertensive peptides: production, bioavailability and incorporation into foods. PMID21185549 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21185549/
RECORD: Rec_0263790 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
ACE-inhibitory peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
ACE
4.1 pIC50
pIC50
PaperWhat are the ideal properties for functional food peptides with antihypertensive effect? A computational peptidology approach. PMID23871047 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23871047/
RECORD: Rec_0265507 VERIFIED: NO
Provenance & Taxonomy
Ovis aries [Animal]
ACE-inhibitory peptide
9940
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
ACE
82.4 μM
IC50
PaperBioactive Peptides of Buffalo, Camel, Goat, Sheep, Mare, and Yak Milks and Milk Products PMID10735560 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10735560/
RECORD: Rec_0280650 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Regulatory
PaperMigliore-Samour D., Roch-Arveiller M., Tissot M., Jazziri M., Keddad K., Giroud J-P., Jolles P.. Effects of tripeptides derived from milk proteins on polymorphonuclear oxidative and phosphoinositide metabolisms. Biochem. Pharmacol., 44, 673-680, 1992.
RECORD: Rec_0323241 VERIFIED: YES
Provenance & Taxonomy
Capra hircus [Animal]
beta-Lactoglobulin-derived
9925
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
ACE inhibitory Antihypertensive Macrophage-modulating
Angiotensin-converting enzyme (ACE)
94.79 μM
IC50
PaperIn Silico and In Vitro Analysis of Multifunctionality of Animal Food-Derived Peptides | Amigo, L. et al. | DOI: 10.3390/foods9080991 Evidence URLhttps://www.uniprot.org/uniprotkb/P02756/entry
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