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MYP_060594
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Basic Information
#5652 derived from HIV-1 integrase
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Reverse transcriptase inhibition
Standard
15 amino acids
C72H108N20O23S2
Standard
Sequence
MHGQVDCSPGIWQLD
Physicochemical Analysis
1685.88 Da
4.51
-2.42
-2.70
-0.1611
-0.29
0.18
0.15
49.19
71.33
0.0667
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
687.41
-6.45
23.0
24.0
52.0
117.0
4.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0122073 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Replication inhibition
HIV-1
30 μM
% inhibition
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperInhibition of human immunodeficiency virus type-1 reverse transcriptase by a novel peptide derived from the viral integrase. | Oz Gleenberg I, Herschhorn A, Goldgur Y, Hizi A. | Arch Biochem Biophys. 2007 Feb 15;458(2):202-12. | DOI:10.1016/j.abb.2006.12.007 | PMID:17257575 PMID17257575 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17257575/
RECORD: Rec_0281243 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Reverse transcriptase inhibition
Qualitative inhibition
PaperInhibition of human immunodeficiency virus type-1 reverse transcriptase by a novel peptide derived from the viral integrase. PMID17257575 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17257575/
RECORD: Rec_0304091 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1[80-90% RT activity = 30 microM
PMID17257575 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17257575/
RECORD: Rec_0304380 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 17257575 PMID17257575 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17257575/
RECORD: Rec_0342246 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1: inhibition of reverse transcriptase(RNA-dependent DNA polymerase) activity(79 ± 3% residual DNA polymerase activity at 30 μM)
PaperPubMed PMID: 17257575 PMID17257575 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17257575/
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