Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length460 amino acids

Chemical FormulaC2253H3635N591O650S20

DescriptionStandard

        MFLCCWLVLGALIPATLSIDPGVKVRLTEKGIEYGRQLGMAAMQQKLNSIQVPDFSGKERVSPIGKVRYNLSNIRVLKVGIPKSSVDLVPGTGVTLSIGDAFISLNGRWKVKYLRIIKHSGSFDLNVNGLNIATTISIKTDETGRPAVSSDSCSAAVGSAKVKFHGGGSWLYNLFTRFIDKALRNAMQKQICPRATSVVSDLNPQLKTLNVLAKVDKYAEIEYSMVSSPTVLKSSIDLSLKGEFYNIGKHQEPPFSPAAFNLPPQNNNMLYIGMSAFTVNSAAFVYNNAGVLSLSVTDDMIPKSSPIRLNTNTFGVIIPGIAKQFPGLMMKLLMKMEKIPTLTFETNNASVQATTTVTAFAIQTNSTLSPLFVLNLEASVSARMFVSEMKLAAAVTLNKMDLTLAKSNVGDFQVRSAFLYNNIQLAKGYPLPTIGKMKLVNTQLNVLKDYILIGTDVQFS
    

Molecular Weight50042.83 Da

Isoelectric Point (pI)9.64

Net Charge (pH 7.0)17.73

Net Charge (pH 7.4) 17.20

Charge Density (pH 7.0) 0.0385

GRAVY Index0.13

Hydrophobic Moment 0.93

Boman Index0.13

Instability Index31.31

Aliphatic Index 100.02

Aromaticity 0.0783

Extinction Coeff. Reduced 34380.00

Extinction Coeff. Oxidized 34630.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0231739 VERIFIED: NO

Provenance & Taxonomy

OrganismOreochromis aureus (Israeli tilapia) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria